HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → HCID 70215951, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | 3-(2-Amino-4,5-dimethoxyphenyl)-2-methyl-2-propenoic acid phenethyl amide | HCID 70214889 | — |
| Reactant | HCID 70215802 | HCID 70215802 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 70215951 | HCID 70215951 | 94% |
Reaction Steps
Into 10 ml of tetrahydrofuran (THF), 1.24 g (5.18 mmol) of (E) ethyl 3-(2-aminophenyl-4-chlorophenyl)-2-methyl-2-propenate were dissolved; and, with 10 ml of a 1-N aqueous sodium hydroxide solution being added thereto, the mixture was reacted at 40° C. for 4 hours. After the completion of the reaction was verified by TLC, the mixture was cooled with 10 ml of 1-N hydrochloric acid being added thereto. The precipitated crystal was filtered out, whereby 1.03 g of the aimed compound were obtained (yield: 94%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06229020B1 |
| Source dataset | uspto-grants-2001_05 |
| ORD ID | ord-0a1156d324004ce29b58bcd808016496 |
| Source note | uspto-grants-2001_05 |