Hydrochloric Acid → HCID 70215951, compound

HRID 1976899Notes

Reaction equation

HRID 1976899 reaction equation
C([NH:9]C(=O)C(C)=CC1C=C(OC)C(OC)=CC=1N)CC1C=CC=CC=1.NC1C=CC=CC=1[C:33]1[CH:38]=[C:37]([Cl:39])[CH:36]=[CH:35][C:34]=1[CH:40]=[C:41]([CH3:47])[C:42]([O:44]CC)=[O:43].[OH-].[Na+].Cl>O1CCCC1>[NH2:9][C:33]1[CH:38]=[C:37]([Cl:39])[CH:36]=[CH:35][C:34]=1[CH:40]=[C:41]([CH3:47])[C:42]([OH:44])=[O:43]

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 702148893-(2-Amino-4,5-dimethoxyphenyl)-2-methyl-2-propenoic acid phenethyl amideHCID 70215802HCID 70215802, compound

Product 1

HCID 70215951HCID 70215951, compoundYield 94%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

Into 10 ml of tetrahydrofuran (THF), 1.24 g (5.18 mmol) of (E) ethyl 3-(2-aminophenyl-4-chlorophenyl)-2-methyl-2-propenate were dissolved; and, with 10 ml of a 1-N aqueous sodium hydroxide solution being added thereto, the mixture was reacted at 40° C. for 4 hours. After the completion of the reaction was verified by TLC, the mixture was cooled with 10 ml of 1-N hydrochloric acid being added thereto. The precipitated crystal was filtered out, whereby 1.03 g of the aimed compound were obtained (yield: 94%).

Workup

  1. customthe mixture was reacted at 40° C. for 4 hours
  2. additionadded
  3. filtrationThe precipitated crystal was filtered out

Sources & evidence

ORD record
ord-0a1156d324004ce29b58bcd808016496
Source dataset
uspto-grants-2001_05
Patent number
US06229020B1

Reaction notes

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