2-Chloro-4-hydroxybenzoic acid → HCID 57193022, compound

HRID 1976993Notes

Reaction equation

HRID 1976993 reaction equation
[CH3:1][O:2][C:3](=[O:24])[C@H:4]([CH2:6][C:7]1[CH:12]=[CH:11][C:10]([NH:13][C:14]([C:16]2[C:21]([Cl:22])=[CH:20][CH:19]=[CH:18][C:17]=2[Cl:23])=[O:15])=[CH:9][CH:8]=1)[NH2:5].[Cl:25][C:26]1[CH:34]=[C:33]([OH:35])[CH:32]=[CH:31][C:27]=1[C:28](O)=[O:29]>>[CH3:1][O:2][C:3](=[O:24])[C@H:4]([CH2:6][C:7]1[CH:8]=[CH:9][C:10]([NH:13][C:14]([C:16]2[C:21]([Cl:22])=[CH:20][CH:19]=[CH:18][C:17]=2[Cl:23])=[O:15])=[CH:11][CH:12]=1)[NH:5][C:28]([C:27]1[CH:31]=[CH:32][C:33]([OH:35])=[CH:34][C:26]=1[Cl:25])=[O:29]

Participants

3

Reactant 2

HCID 918212-Chloro-4-hydroxybenzoic acidHCID 233839334-(2,6-Dichlorobenzoylamino)-L-phenylalanine methyl ester

Product 1

HCID 57193022HCID 57193022, compoundYield 35%

Procedure

4-[[(2,6-Dichlorophenyl)carbonyl]amino]-N-[(2-chloro4-hydroxyphenyl)carbonyl]-L-phenylalanine methyl ester was prepared in 35% yield from 4-[[(2,6-dichlorophenyl)carbonyl]amino]-L-phenylalanine methyl ester and 2-chloro-4-hydroxybenzoic acid using the general procedure described in example 3. HR MS: Obs. mass, 521.0433. Calcd. mass, 521.0438 (M+H).

Sources & evidence

ORD record
ord-4d3f35f05489473cb5be402eaf52d223
Source dataset
uspto-grants-2001_05
Patent number
US06229011B1

Reaction notes

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