反应详情

Nonyl anisole was prepared from nonylphenol, available from Jefferson Chemicals, and methyl iodide under typical Williamson ether synthesis conditions. Nonylphenol (1.0 mole), methyl iodide (1.2 moles), potassium carbonate (1.25 moles) and acetone were placed in a round bottom flask and heated to reflux. After refluxing overnight, the reaction mixture was poured into water and extracted with ether. The ether extract was washed with saturated sodium chloride solution, dried and evaporated to an oil which was then purified by vacuum distillation. The product was analyzed as nonyl anisole by IR and NMR spectroscopy.

1. temperatureheated to reflux
2. temperatureAfter refluxing overnight
3. extractionextracted with ether
4. extractionThe ether extract
5. washwas washed with saturated sodium chloride solution
6. customdried
7. customevaporated to an oil which
8. distillationwas then purified by vacuum distillation