Hydrochloric Acid → HCID 86585868, compound

HRID 1977024Notes

Reaction equation

HRID 1977024 reaction equation
[Cl:1][C:2]1[N:3]=[N:4][C:5](Cl)=[CH:6][CH:7]=1.[F:9][C:10]1[CH:27]=[CH:26][C:13]([O:14][CH2:15][C@H:16]2[CH2:25][N:20]3[CH2:21][CH2:22][NH:23][CH2:24][C@@H:19]3[CH2:18][CH2:17]2)=[CH:12][CH:11]=1.Cl>>[F:9][C:10]1[CH:11]=[CH:12][C:13]([O:14][CH2:15][C@H:16]2[CH2:25][N:20]3[CH2:21][CH2:22][N:23]([C:5]4[N:4]=[N:3][C:2]([Cl:1])=[CH:7][CH:6]=4)[CH2:24][C@@H:19]3[CH2:18][CH2:17]2)=[CH:26][CH:27]=1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 673313,6-DichloropyridazineHCID 53849828HCID 53849828, compound

Product 1

HCID 86585868HCID 86585868, compound

Procedure

The title compound was prepared according to Preparation 3 with 3,6-dichloropyridazine and (7R,9aS)-7-(4-fluorophenoxy)methyl-2,3,4,6,7,8,9,9a-octahydro-1H-pyrido[1,2-a]pyrazine. mp (—HCl) 265-270° C. 13C NMR (base, CDCl3): δ26.8, 29.0, 36.4, 45.1, 50.4, 54.4, 58.6, 60.3, 71.5, 115.2, 115.3, 115.4, 115.6, 115.9, 128.7, 146.7, 155.0, 155.6, 158.76, 158.82. HRMS calcd for C19H22ClFN4O: 376.1461; found: 376.1453.

Sources & evidence

ORD record
ord-7d1fe4c8833b449fb9a1c8296eb3efb0
Source dataset
uspto-grants-2001_05
Patent number
US06231833B1

Reaction notes

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