Phenol → HCID 20654285, compound

HRID 1977033Notes

Reaction equation

HRID 1977033 reaction equation
[OH:1][CH2:2][CH:3]1[CH2:12][N:7]2[CH2:8][CH2:9][NH:10][CH2:11][CH:6]2[CH2:5][CH2:4]1.[Cl:13][C:14]1[N:19]=[C:18](Cl)[CH:17]=[CH:16][N:15]=1.[C:21]1(O)[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1>>[O:1]([CH2:2][CH:3]1[CH2:12][N:7]2[CH2:8][CH2:9][N:10]([C:16]3[CH:17]=[CH:18][N:19]=[C:14]([Cl:13])[N:15]=3)[CH2:11][CH:6]2[CH2:5][CH2:4]1)[C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1

Participants

4

Reactant 3

HCID 996PhenolHCID 775312,4-DichloropyrimidineHCID 12985539(Octahydro-1H-pyrido[1,2-A]pyrazin-7-YL)methanol

Product 1

HCID 20654285HCID 20654285, compound

Procedure

A mixture of (7RS,9aSR)-7-hydroxymethyl-2,3,4,6,7,8,9,9a-octahydro-1H-pyrido[1,2-a]pyrazine (U.S. Pat. No. 5,326,874) and 2,4-dichloropyrimidine were combined according to Preparation 3. The product from this reaction was coupled with phenol according to Example 1 to give the title compound. mp (—HCl) 227-233° C. (dec). HRMS calcd for C19H23ClN4O: 358.1560, found: 358.1560.

Sources & evidence

ORD record
ord-d832f5d39e96404c8f57e917e29ccbd0
Source dataset
uspto-grants-2001_05
Patent number
US06231833B1

Reaction notes

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