4-Fluorophenol → HCID 21997244, compound

HRID 1977036Notes

Reaction equation

HRID 1977036 reaction equation
[OH:1][CH2:2][CH:3]1[CH2:12][N:7]2[CH2:8][CH2:9][NH:10][CH2:11][CH:6]2[CH2:5][CH2:4]1.[Cl:13][C:14]1[N:15]=[N:16][C:17](Cl)=[CH:18][CH:19]=1.[F:21][C:22]1[CH:27]=[CH:26][C:25](O)=[CH:24][CH:23]=1>>[F:21][C:22]1[CH:27]=[CH:26][C:25]([O:1][CH2:2][CH:3]2[CH2:12][N:7]3[CH2:8][CH2:9][N:10]([C:17]4[N:16]=[N:15][C:14]([Cl:13])=[CH:19][CH:18]=4)[CH2:11][CH:6]3[CH2:5][CH2:4]2)=[CH:24][CH:23]=1

Participants

4

Reactant 3

HCID 97324-FluorophenolHCID 673313,6-DichloropyridazineHCID 12985539(Octahydro-1H-pyrido[1,2-A]pyrazin-7-YL)methanol

Product 1

HCID 21997244HCID 21997244, compound

Procedure

A mixture of (7RS,9aSR)-7-hydroxymethyl-2,3,4,6,7,8,9,9a-octahydro-1H-pyrido[1,2-a]pyrazine (U.S. Pat. No. 5,326,874) and 3,6-di-chloropyridazine were combined according to Preparation 3. The product from this reaction was coupled with 4-fluorophenol according to Example 1 to give the title compound. mp (—HCl) 255° C. (dec). HRMS calc for C19H22ClFN4O: 376.1461, found: 376.1458.

Sources & evidence

ORD record
ord-765b6c8467bd43e880e517c34c2b7b00
Source dataset
uspto-grants-2001_05
Patent number
US06231833B1

Reaction notes

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