Phenol → HCID 20654294, compound

HRID 1977037Notes

Reaction equation

HRID 1977037 reaction equation
[OH:1][CH2:2][CH:3]1[CH2:12][N:7]2[CH2:8][CH2:9][NH:10][CH2:11][CH:6]2[CH2:5][CH2:4]1.[Cl:13][C:14]1[N:15]=[N:16][C:17](Cl)=[CH:18][CH:19]=1.[C:21]1(O)[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1>>[O:1]([CH2:2][CH:3]1[CH2:12][N:7]2[CH2:8][CH2:9][N:10]([C:17]3[N:16]=[N:15][C:14]([Cl:13])=[CH:19][CH:18]=3)[CH2:11][CH:6]2[CH2:5][CH2:4]1)[C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1

Participants

4

Reactant 3

HCID 996PhenolHCID 673313,6-DichloropyridazineHCID 12985539(Octahydro-1H-pyrido[1,2-A]pyrazin-7-YL)methanol

Product 1

HCID 20654294HCID 20654294, compound

Procedure

A mixture of (7RS,9aSR)-7-hydroxymethyl-2,3,4,6,7,8,9,9a-octahydro-1H-pyrido[1,2-a]pyrazine (U.S. Pat. No. 5,326,874) and 3,6-dichloropyridazine were combined according to Preparation 3. The product from this reaction was coupled with phenol according to Example 1 to give the title compound. mp (—HCl) >265° C. (dec). HRMS calcd for C19H23ClN4O: 358.1555, found: 358.1550.

Sources & evidence

ORD record
ord-8118f06a171e4896be606f4a7ab5f6db
Source dataset
uspto-grants-2001_05
Patent number
US06231833B1

Reaction notes

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