Hydrochloric Acid → HCID 69430557, compound

HRID 1977048Notes

Reaction equation

HRID 1977048 reaction equation
C([N:8]1[CH2:13][CH2:12][N:11]2[CH2:14][C@H:15]([CH2:18][N:19]3[C:27]4[C:22](=[CH:23][CH:24]=[CH:25][CH:26]=4)[CH2:21][C:20]3=[O:28])[CH2:16][CH2:17][C@H:10]2[CH2:9]1)(OC(C)(C)C)=O.[ClH:29]>C(Cl)(Cl)Cl.C(OCC)C>[ClH:29].[ClH:29].[CH2:9]1[NH:8][CH2:13][CH2:12][N:11]2[CH2:14][C@H:15]([CH2:18][N:19]3[C:27]4[C:22](=[CH:23][CH:24]=[CH:25][CH:26]=4)[CH2:21][C:20]3=[O:28])[CH2:16][CH2:17][C@@H:10]12

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 22940596HCID 22940596, compound

Product 1

HCID 69430557HCID 69430557, compoundYield 100%

Reagents, catalysts & solvents 2

HCID 3283Diethyl EtherSolventHCID 6212ChloroformSolvent

Procedure

A solution of 0.53 g (1.38 mmol) of 1-[(7R,9aS)-2-BOC-2,3,4,6,7,8,9,9a-octahydro-1H-pyrido[1,2-a]pyrazin-7-ylmethyl]-1,3-dihydro-indol-2-one in 10 mL of chloroform was treated with excess HCl(g) in ethyl ether and stirred at room temperature for 1 h. The solvent was evaporated to give 0.49 g (100%) of 1-[(7R,9aS)-2,3,4,6,7,8,9,9a-octahydro-1H-pyrido[1,2-a]pyrazin-7-ylmethyl]-1,3-dihydro-indol-2-one dihydrochloride.

Workup

  1. customThe solvent was evaporated

Sources & evidence

ORD record
ord-cac96cbf629d4075904fc1934a3970d2
Source dataset
uspto-grants-2001_05
Patent number
US06231833B1

Reaction notes

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