Ziprasidone → HCID 86583591, compound

HRID 1977091Notes

Reaction equation

HRID 1977091 reaction equation
[CH:1]1[CH:2]=[CH:3][C:4]2[S:9][N:8]=[C:7]([N:10]3[CH2:15][CH2:14][N:13]([CH2:16][CH2:17][C:18]4[CH:19]=[C:20]5[CH2:28][C:26](=[O:27])[NH:25][C:21]5=[CH:22][C:23]=4[Cl:24])[CH2:12][CH2:11]3)[C:5]=2[CH:6]=1.[C:29]([OH:38])(=[O:37])[C@@H:30]([C@H:32]([C:34]([OH:36])=[O:35])[OH:33])[OH:31]>O>[CH:1]1[CH:2]=[CH:3][C:4]2[S:9][N:8]=[C:7]([N:10]3[CH2:11][CH2:12][N:13]([CH2:16][CH2:17][C:18]4[CH:19]=[C:20]5[CH2:28][C:26](=[O:27])[NH:25][C:21]5=[CH:22][C:23]=4[Cl:24])[CH2:14][CH2:15]3)[C:5]=2[CH:6]=1.[C:34]([CH:32]([CH:30]([C:29]([O-:38])=[O:37])[OH:31])[OH:33])([O-:36])=[O:35]

Participants

4

Reactant 2

HCID 60854ZiprasidoneHCID 444305L-Tartaric acid

Product 1

HCID 86583591HCID 86583591, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
50 °C

Procedure

1 g of ziprasidone free base was added to 60 mL of water and the resulting slurry was heated to 50° C. for 3 hours with stirring. 900 mg of L-tartaric acid was added. Heating at 50° C. and stiring were continued for 6 more hours, and then the mixture was stirred at 40° C. overnight. The solution was then allowed to cool and the salt harvested as in Example 5.

Workup

  1. temperatureHeating at 50° C.
  2. stirringthe mixture was stirred at 40° C. overnight
  3. temperatureto cool

Sources & evidence

ORD record
ord-170d8bd3e3314b6481c2fb3e02be2da5
Source dataset
uspto-grants-2001_05
Patent number
US06232304B1

Reaction notes

Loading…