Sodium Hydroxide → HCID 9859540, compound

HRID 1977124Notes

Reaction equation

[C:1]([CH2:3][S:4]([C:7]1[CH:12]=[CH:11][C:10]([F:13])=[CH:9][C:8]=1[NH:14][C:15](=O)[CH3:16])(=[O:6])=[O:5])#[N:2].[OH-].[Na+]>>[F:13][C:10]1[CH:11]=[CH:12][C:7]2[S:4](=[O:6])(=[O:5])[C:3]([C:1]#[N:2])=[C:15]([CH3:16])[NH:14][C:8]=2[CH:9]=1

Participants

Reactant 2

HCID 14798Sodium Hydroxide

HCID 21997629HCID 21997629, compound

Product 1

HCID 9859540HCID 9859540, compound

Procedure

Treatment of N-(2-cyanomethylsulfonyl-5-fluoro-phenyl)acetamide with aqueous sodium hydroxide by a procedure similar to the procedure described in EXAMPLE 1 c) gave the title compound; mp 261-263° C. (sinters at 240-251° C.), 1H-NMR (DMSO-d6), δ (ppm): 12.03 (br s, 1H, NH), 8.06 (dd, 9.0 Hz/5.5 Hz, 1H, H8), 7.35 (m, 1H, H7), 7.20 (dd, 10.0/2.5 Hz, 1H, H5), 2.46 (s, 3H, CH3).

Sources & evidence

ORD record: ord-28baac0dff904b92bcdcdff4877ba0d8
Source dataset: uspto-grants-2001_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06232310B1

Reaction notes

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