Piperazine → 1-Propanone, 1-(4-chlorophenyl)-3-(1-piperazinyl)-

HRID 1977127Notes

Reaction equation

Cl[CH2:2][CH2:3][C:4]([C:6]1[CH:11]=[CH:10][C:9]([Cl:12])=[CH:8][CH:7]=1)=[O:5].[NH:13]1[CH2:18][CH2:17][NH:16][CH2:15][CH2:14]1>>[Cl:12][C:9]1[CH:10]=[CH:11][C:6]([C:4](=[O:5])[CH2:3][CH2:2][N:13]2[CH2:18][CH2:17][NH:16][CH2:15][CH2:14]2)=[CH:7][CH:8]=1

Participants

Reactant 2

HCID 4837Piperazine

HCID 775503,4'-Dichloropropiophenone

Product 1

HCID 4154061-Propanone, 1-(4-chlorophenyl)-3-(1-piperazinyl)-

Procedure

4′-Chloro-3-(piperazin-1-yl)propiophenone was prepared from commercially available 3,4′-dichloropropiophenone (Aldrich, 14,159-3) and piperazine according to the general methodology described at step A of example 1.

Sources & evidence

ORD record: ord-d22555d557814aba92eca94e4318adcd
Source dataset: uspto-grants-2001_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06232314B1

Reaction notes

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