4'-Hydroxy-4-biphenylcarboxylic acid → Methyl 4'-hydroxy(1,1'-biphenyl)-4-carboxylate

HRID 1977270Notes

Reaction equation

HRID 1977270 reaction equation
[OH:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:16]=[CH:15][C:11]([C:12]([OH:14])=[O:13])=[CH:10][CH:9]=2)=[CH:4][CH:3]=1.Cl.[CH3:18]O>>[OH:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[CH:16]=[CH:15][C:11]([C:12]([O:14][CH3:18])=[O:13])=[CH:10][CH:9]=2)=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 3015564'-Hydroxy-4-biphenylcarboxylic acidHCID 21893726Hydrochloride methanol

Product 1

HCID 1490289Methyl 4'-hydroxy(1,1'-biphenyl)-4-carboxylate

Procedure

A solution of 4-(4′-hydroxyphenyl)benzoic acid (25.6 g) in 10% hydrochloric acid-methanol was stirred for 3 days at room temperature. Then the solvent was evaporated in vacuo and the residue was triturated with toluene-ethyl acetate (20:1) to afford methyl 4-(4′-hydroxyphenyl)benzoate (26.5 g).

Workup

  1. customThen the solvent was evaporated in vacuo
  2. customthe residue was triturated with toluene-ethyl acetate (20:1)

Sources & evidence

ORD record
ord-930c20934dd64b0f8000cd77c91c6aab
Source dataset
uspto-grants-2001_05
Patent number
US06232290B1

Reaction notes

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