Water → 2,3-Dihydro-1h-inden-2-yl methanesulfonate

HRID 1977287Notes

Reaction equation

HRID 1977287 reaction equation
[CH2:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH2:3][CH:2]1[OH:10].C(N(CC)CC)C.[CH3:18][S:19](Cl)(=[O:21])=[O:20].O>ClCCl>[CH2:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH2:3][CH:2]1[O:10][S:19]([CH3:18])(=[O:21])=[O:20]

Participants

6

Reactant 4

HCID 962WaterHCID 8471TriethylamineHCID 31297Methanesulfonyl chlorideHCID 779362-Indanol

Product 1

HCID 2552212,3-Dihydro-1h-inden-2-yl methanesulfonate

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent2×

Procedure

To a solution of 2-indanol (4 g) and triethylamine (5.8 ml) in dichloromethane (40 ml) was added dropwise with stirring methanesulfonylchloride (2.8 ml) in an ice-bath. The mixture was then stirred for 1.5 hours. The reaction mixture was added to a mixture of water and dichloromethane. The organic layer was taken and dried over magnesium sulfate. The magnesium sulfate was filtered off, and the filtrate was concentrated under reduced pressure to give methanesulfonic acid indan-2-yl ester (6.29 g).

Workup

  1. dry with materialdried over magnesium sulfate
  2. filtrationThe magnesium sulfate was filtered off
  3. concentrationthe filtrate was concentrated under reduced pressure

Sources & evidence

ORD record
ord-8ca8595dedb947b18cef87fbfddfafad
Source dataset
uspto-grants-2001_05
Patent number
US06232290B1

Reaction notes

Loading…