Sodium Hydroxide → HCID 712932, compound

HRID 1977288Notes

Reaction equation

HRID 1977288 reaction equation
FC(F)(F)C(O)=O.C[O:9][C:10](=[O:23])[C:11]1[CH:16]=[CH:15][C:14]([C:17]2[S:18][C:19]([NH2:22])=[N:20][N:21]=2)=[CH:13][CH:12]=1.[OH-].[Na+]>O>[NH2:22][C:19]1[S:18][C:17]([C:14]2[CH:13]=[CH:12][C:11]([C:10]([OH:23])=[O:9])=[CH:16][CH:15]=2)=[N:21][N:20]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 70053962HCID 70053962, compound

Product 1

HCID 712932HCID 712932, compoundYield 99.7%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

To a solution of 4-(5-amino-1,3,4-thiadiazol-2-yl)benzoic acid methyl ester trifluoroacetic acid salt (8 g) in water was added 1N sodium hydroxide and the mixture was adjusted to pH 8. The precipitate was collected by filtration to give 4-(5-amino-1,3,4-thiadiazol-2-yl)benzoic acid (5.05 g).

Workup

  1. filtrationThe precipitate was collected by filtration

Sources & evidence

ORD record
ord-46f2294dd12648d88ddd4544db7fcdd9
Source dataset
uspto-grants-2001_05
Patent number
US06232290B1

Reaction notes

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