Benzenemethanamine, 3,4-dichloro- → HCID 18617109, compound

HRID 1977363Notes

Reaction equation

HRID 1977363 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([CH:7]=[CH:8][C:9]=1[Cl:10])[CH2:5][NH2:6].[Cl:11][S:12]([C:15]1[CH:16]=[C:17]([CH:21]=[CH:22][CH:23]=1)[C:18](Cl)=[O:19])(=[O:14])=[O:13].COC(=O)[C@@H](NC(=O)C1C=CC=C(S(Cl)(=O)=O)C=1)CCS(C)(=O)=O>>[Cl:1][C:2]1[CH:3]=[C:4]([CH:7]=[CH:8][C:9]=1[Cl:10])[CH2:5][NH:6][C:18]([C:17]1[CH:16]=[C:15]([S:12]([Cl:11])(=[O:14])=[O:13])[CH:23]=[CH:22][CH:21]=1)=[O:19]

Participants

4

Reactant 3

HCID 1608Benzenemethanamine, 3,4-dichloro-HCID 77671Benzoyl chloride, 3-(chlorosulfonyl)-HCID 57282618HCID 57282618, compound

Product 1

HCID 18617109HCID 18617109, compoundYield 28%

Procedure

Starting material (17(c)) was prepared as follows. 3,4-Dichlorobenzylamine was coupled with 3-Chlorosulphonylbenzoyl chloride (analogously as for compound (15(a)) in Example 15) to give 3-(3,4-dichloro-benzylcarbamoyl)-benzene-sulfonyl-chloride (17(a)) in 28% yield.

Workup

  1. customwas prepared

Sources & evidence

ORD record
ord-26b4fca42a4043e489458e0b951107fd
Source dataset
uspto-grants-2001_05
Patent number
US06232338B1

Reaction notes

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