(1,1'-Biphenyl)-4-sulfonic acid → (1,1'-Biphenyl)-4-sulphonyl chloride

HRID 1977486Notes

Reaction equation

HRID 1977486 reaction equation
[C:1]1([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[CH:6]=[CH:5][C:4]([S:7](O)(=[O:9])=[O:8])=[CH:3][CH:2]=1.P(Cl)(Cl)(Cl)(Cl)[Cl:18]>O>[C:1]1([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[CH:6]=[CH:5][C:4]([S:7]([Cl:18])(=[O:9])=[O:8])=[CH:3][CH:2]=1

Participants

4

Reactant 2

HCID 16673(1,1'-Biphenyl)-4-sulfonic acidHCID 24819Phosphorus pentachloride

Product 1

HCID 74192(1,1'-Biphenyl)-4-sulphonyl chloride

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

4-Biphenyl sulfonic acid (2.4 g, 10 mmol) was heated to 100 C. with phosphorus pentachloride (2.1 g, 10 mmol) overnight. The reaction was cooled to RT, diluted with water, filtered and washed with water. The solid was then triturated with EtOAc-ether and the beige solid was used in the next reaction without further purification.

Workup

  1. filtrationfiltered
  2. washwashed with water
  3. customThe solid was then triturated with EtOAc-ether
  4. customthe beige solid was used in the next reaction without further purification

Sources & evidence

ORD record
ord-0067f39eff8b46d1aaa637986126e150
Source dataset
uspto-grants-2001_05
Patent number
US06232342B1

Reaction notes

Loading…