Acetic Anhydride → N-(3,5-Dichloro-2-hydroxy-4-methylphenyl)acetamide

HRID 1977538Notes

Reaction equation

HRID 1977538 reaction equation
[NH2:1][C:2]1[CH:7]=[C:6]([Cl:8])[C:5]([CH3:9])=[C:4]([Cl:10])[C:3]=1[OH:11].[C:12](OC(=O)C)(=[O:14])[CH3:13]>C(O)(=O)C>[C:12]([NH:1][C:2]1[CH:7]=[C:6]([Cl:8])[C:5]([CH3:9])=[C:4]([Cl:10])[C:3]=1[OH:11])(=[O:14])[CH3:13]

Participants

4

Reactant 2

HCID 7918Acetic AnhydrideHCID 1702242-Amino-4,6-dichloro-5-methylphenol

Product 1

HCID 13796880N-(3,5-Dichloro-2-hydroxy-4-methylphenyl)acetamide

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

The product from Example 9, Stage 1a (4.8 g), was stirred in acetic acid (20 ml) and acetic anhydride (5 ml) was added in one portion. Stirring was continued for 1hour after the initially exothermic reaction had subsided. The product was isolated by filtration and recrystallised from aqueous ethanol.

Workup

  1. customafter the initially exothermic reaction
  2. customThe product was isolated by filtration
  3. customrecrystallised from aqueous ethanol

Sources & evidence

ORD record
ord-50c96833c52540fa94a6694323f546a3
Source dataset
uspto-grants-2001_05
Patent number
US06235096B1

Reaction notes

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