Bromopentafluorobenzene → HCID 178505971, compound
Reaction equation
C([Mg:3][Br:4])C.Br[C:6]1[C:11]([F:12])=[C:10]([F:13])[C:9]([F:14])=[C:8]([F:15])[C:7]=1[F:16]>O1CCCC1>[F:12][C:11]1[C:6]([Mg:3][Br:4])=[C:7]([F:16])[C:8]([F:15])=[C:9]([F:14])[C:10]=1[F:13]Participants
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 35 °C
Procedure
Air inside a reaction vessel of the same type as the one used in Example 1 was replaced with a nitrogen gas in a satisfactory manner, after which 50 ml of a tetrahydrofuran solution containing 0.018 mol of ethyl magnesium bromide was charged to the reaction vessel. Meanwhile, 0.018 mol of bromopentafluorobenzene was charged to the dropping funnel. Then, bromopentafluorobenzene in the dropping funnel was dropped to the reaction vessel over 10 minutes at room temperature with the stirring of the tetrahydrofuran solution in the reaction vessel, and the reaction solution was heated to 35° C. for 1 hour. Consequently, pentafluorophenyl magnesium bromide was obtained in the form of a light yellow tetrahydrofuran solution. The yield of pentafluorophenyl magnesium bromide measured in the same manner as Example 1 was 93.9 mol % based on bromopentafluorobenzene.
Workup
- customAir inside a reaction vessel of the same type as the one used in Example 1
- additionwas charged to the reaction vessel
Sources & evidence
- ORD record
- ord-7f736193d49a45a190ff885fe11a1a9a
- Source dataset
- uspto-grants-2001_05
- Patent number
- US06235222B1
Reaction notes
Loading…