Triethylamine → HCID 21993392, compound

HRID 1977569Notes

Reaction equation

HRID 1977569 reaction equation
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([S:10]([NH2:13])(=[O:12])=[O:11])=[CH:6][CH:5]=1)([O-:3])=[O:2].C(N(CC)CC)C.[C:21](Cl)(=[O:30])[C:22]1[C:23]([O:28][CH3:29])=[CH:24][CH:25]=[CH:26][CH:27]=1>C(#N)C>[CH3:29][O:28][C:23]1[CH:24]=[CH:25][CH:26]=[CH:27][C:22]=1[C:21]([NH:13][S:10]([C:7]1[CH:6]=[CH:5][C:4]([N+:1]([O-:3])=[O:2])=[CH:9][CH:8]=1)(=[O:11])=[O:12])=[O:30]

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 227844-NitrobenzenesulfonamideHCID 889692-Methoxybenzoyl chloride

Product 1

HCID 21993392HCID 21993392, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent2×

Procedure

30.0 g (0.15 mol) of 4-nitrobenzenesulfonamide are treated with 30.0 g (0.3 mol) of triethylamine in 300 ml of acetonitrile and, at 50° C., treated with 27.8 g (0.16 mol) of o-anisoyl chloride, dissolved in 20 ml of acetonitrile. After 3 hours at 50° C., the mixture is stirred into 80 ml of ice-water, and the precipitate is filtered off with suction and dried. More product can be obtained by acidifying the mother liquor;

Workup

  1. filtrationthe precipitate is filtered off with suction
  2. customdried
  3. customMore product can be obtained

Sources & evidence

ORD record
ord-ff4889aa225744e0ba65cd09b2d4ac54
Source dataset
uspto-grants-2001_05
Patent number
US06235680B1

Reaction notes

Loading…