Pyridine → HCID 751448, compound

HRID 1977572Notes

Reaction equation

HRID 1977572 reaction equation
[S:1]([NH2:11])(=[O:10])([C:3]1[CH:8]=[CH:7][C:6]([NH2:9])=[CH:5][CH:4]=1)=[O:2].N1C=CC=CC=1.[Cl:18][C:19]1[CH:27]=[C:26]([Cl:28])[CH:25]=[CH:24][C:20]=1[C:21](Cl)=[O:22]>O1CCOCC1.O>[S:1]([C:3]1[CH:4]=[CH:5][C:6]([NH:9][C:21](=[O:22])[C:20]2[CH:24]=[CH:25][C:26]([Cl:28])=[CH:27][C:19]=2[Cl:18])=[CH:7][CH:8]=1)(=[O:10])(=[O:2])[NH2:11]

Participants

6

Reactant 3

HCID 1049PyridineHCID 5333SulfanilamideHCID 666452,4-Dichlorobenzoyl chloride

Product 1

HCID 751448HCID 751448, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 312751,4-DioxaneSolvent

Procedure

10 g (60mmol) of sulfanilamide are suspended in 150 ml of dioxane and 4.6 g (60 mmol) of pyridine are added. 12.2 g (60 mmol) of 2,4-dichloro-benzoyl chloride are then added at 0° C., and stirring is continued for 2 hours at room temperature. The mixture is stirred in 200 ml of water, and the precipitate which separates out is filtered off with suction and dried;

Workup

  1. filtrationthe precipitate which separates out is filtered off with suction
  2. customdried

Sources & evidence

ORD record
ord-3727ec9beea74922a28e633f73589911
Source dataset
uspto-grants-2001_05
Patent number
US06235680B1

Reaction notes

Loading…