反应详情

温度

22 °C

250 mg (1.6 mmol) of (R)-(1-amino-2-methylpropyl)phosphonic acid were dissolved in 6 ml of a 1 M NaOH and 6 ml of tetrahydrofuran. 560 mg (1.96 mmol) of 4-chlorobiphenyl-4′-sulfonyl chloride were then added and the mixture was stirred at 22° C. overnight. The reaction mixture was concentrated, acidified with 2 M HCl and extracted with ethyl acetate. The 4-chlorobiphenyl-4′-sulfonic acid resulting as a by-product precipitated and was separated off. After drying and concentrating the ethyl acetate phase, a solid was obtained.

1. concentrationThe reaction mixture was concentrated
2. extractionextracted with ethyl acetate
3. customThe 4-chlorobiphenyl-4′-sulfonic acid resulting as a by-product precipitated
4. customwas separated off
5. customAfter drying
6. concentrationconcentrating the ethyl acetate phase
7. customa solid was obtained