反应详情

1.04 g (5.02 mole) of 3-cyclopentyloxy-4-methoxyaniline, 0.51 g (5.02 mmole) of 1,3-cyclopentanedione, and 0.03 g of p-toluenesulfonic acid were dissolved in 30 ml of benzene and the solution was heated reflux in an apparatus fitted with a water separation tube for 3 hours, while azeotropically separating the water produced. After the reaction, the solution was cooled to room temperature, a yellow crystal was precipitated. The precipitated yellow crystal was collected by suction filtration, and the crystal was washed with diethyl ether, then dried to obtain the title compound 1.16 g (yield 80.4%) as a pale yellow crystal.

1. temperaturethe solution was heated
2. temperaturereflux in an apparatus
3. customwhile azeotropically separating the water
4. customproduced
5. customAfter the reaction
6. customa yellow crystal was precipitated
7. filtrationThe precipitated yellow crystal was collected by suction filtration
8. washthe crystal was washed with diethyl ether
9. customdried