Benzyl Bromide → HCID 10200481, compound

HRID 1977604Notes

Reaction equation

[CH:1]1([O:7][C:8]2[CH:9]=[C:10]([CH:18]=[CH:19][C:20]=2[O:21][CH3:22])[NH:11][C:12]2[CH2:16][CH2:15][C:14](=[O:17])[CH:13]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[CH2:23](Br)[C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1>>[CH2:23]([N:11]([C:12]1[CH2:16][CH2:15][C:14](=[O:17])[CH:13]=1)[C:10]1[CH:18]=[CH:19][C:20]([O:21][CH3:22])=[C:8]([O:7][CH:1]2[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]2)[CH:9]=1)[C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1

Participants

Reactant 2

HCID 7498Benzyl Bromide

HCID 21994389HCID 21994389, compound

Product 1

HCID 10200481HCID 10200481, compoundYield 89.4%

Procedure

According to the same procedure as in Example 26, using 3-(3-cyclohexyloxy-4-methoxyanilino)-2-cyclopenten-1-one produced in Example 13(3) instead of 3-(3-cyclopentyloxy-4-methoxyanilino)-2-cyclopenten-1-one, and using benzyl bromide instead of methyl iodide, the title compound (yield 89.4%) was obtained as a yellow oil.

Sources & evidence

ORD record: ord-49d0d90a004f43149c68a0b4f867b0d3
Source dataset: uspto-grants-2001_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06235736B1

Reaction notes

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