Benzyl Bromide → HCID 10294599, compound

HRID 1977606Notes

Reaction equation

[CH:1]12[CH2:7][CH:4]([CH2:5][CH2:6]1)[CH2:3][CH:2]2[O:8][C:9]1[CH:10]=[C:11]([CH:19]=[CH:20][C:21]=1[O:22][CH3:23])[NH:12][C:13]1[CH2:17][CH2:16][C:15](=[O:18])[CH:14]=1.[CH2:24](Br)[C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=1>>[CH2:24]([N:12]([C:13]1[CH2:17][CH2:16][C:15](=[O:18])[CH:14]=1)[C:11]1[CH:19]=[CH:20][C:21]([O:22][CH3:23])=[C:9]([O:8][CH:2]2[CH2:3][CH:4]3[CH2:7][CH:1]2[CH2:6][CH2:5]3)[CH:10]=1)[C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=1

Participants

Reactant 2

HCID 7498Benzyl Bromide

HCID 68464430HCID 68464430, compound

Product 1

HCID 10294599HCID 10294599, compoundYield 92.3%

Procedure

According to the same procedure as in Example 26, using 3-[3-[(1RS,2RS,4SR)-bicyclo[2.2.1]hept-2-yloxy]-4-methoxyanilino]2-cyclopenten-1-one produced in Example 8(3) instead of 3-(3-cyclopentyloxy-4-methoxyanilino)-2-cyclopenten-1-one, and using benzyl bromide instead of methyl iodide, the title compound (yield 92.3%) was obtained as a light yellow oil.

Sources & evidence

ORD record: ord-b1bf9d6678ea49eaa22c43ed08aa35bb
Source dataset: uspto-grants-2001_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06235736B1

Reaction notes

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