Hydrogen Bromide → HCID 21994461, compound

HRID 1977610Notes

Reaction equation

HRID 1977610 reaction equation
[CH3:1][N:2]([CH3:15])[CH2:3][CH2:4][O:5][C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][C:7]=1[C:12](=[O:14])[CH3:13].Br.C(Cl)Cl.CS(C)=[O:22]>>[CH3:15][N:2]([CH3:1])[CH2:3][CH2:4][O:5][C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][C:7]=1[C:12](=[O:14])[CH:13]=[O:22]

Participants

5

Reactant 4

HCID 260Hydrogen BromideHCID 679Dimethyl SulfoxideHCID 6344DichloromethaneHCID 16403Acetophenone, 2'-(2-(dimethylamino)ethoxy)-

Product 1

HCID 21994461HCID 21994461, compound

Conditions

Temperature
80 °C

Procedure

A solution of 1-[2-(2-dimethylamino-ethoxy)-phenyl]-ethanone (4.35 g) in dimethylsulfoxide (8.8 ml) was added with 48% HBr (1.8 ml). The mixture was stirred at 80° C. for 6 hours under nitrogen stream. Then it was poured into methylene chloride (50 ml) and dried over magnesium sulfate. The mixture was neutralized to pH 7 with solid sodium bicarbonate, then filtered and evaporated under high vacuum at low temperature. The title compound was used without further purification.

Workup

  1. dry with materialdried over magnesium sulfate
  2. filtrationfiltered
  3. customevaporated under high vacuum at low temperature
  4. customThe title compound was used without further purification

Sources & evidence

ORD record
ord-dbdc7a24e90f41e7825d0d84adf8d776
Source dataset
uspto-grants-2001_05
Patent number
US06235738B1

Reaction notes

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