Glyoxylic acid, monohydrate → HCID 135815254, compound

HRID 1977631Notes

Reaction equation

HRID 1977631 reaction equation
[NH2:1][C:2]1[CH:22]=[CH:21][C:5]([CH2:6][C:7]2[NH:8][C:9](=[O:20])[C:10]3[N:15]([CH3:16])[N:14]=[C:13]([CH2:17][CH2:18][CH3:19])[C:11]=3[N:12]=2)=[CH:4][CH:3]=1.O.[C:24]([OH:28])(=[O:27])[CH:25]=O>[Pd].CO>[CH3:16][N:15]1[C:10]2[C:9](=[O:20])[NH:8][C:7]([CH2:6][C:5]3[CH:21]=[CH:22][C:2]([NH:1][CH2:25][C:24]([OH:28])=[O:27])=[CH:3][CH:4]=3)=[N:12][C:11]=2[C:13]([CH2:17][CH2:18][CH3:19])=[N:14]1

Participants

5

Reactant 2

HCID 15620607Glyoxylic acid, monohydrateHCID 1358152625-[(4-Aminophenyl)methyl]-1-methyl-3-propyl-1,4-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one

Product 1

HCID 135815254HCID 135815254, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

10% w/w Palladium on charcoal (87 mg) was added to a solution of 5-(4-aminobenzyl)-1-methyl-3-propyl-6,7-dihydro-1H-pyrazolo[4,3-d]pyrimidin-7-one (870 mg, 0.00293 mol) and glyoxylic acid hydrate (260 mg, 0.0035 mol) in methanol (20 ml) and the mixture hydrogenated at room temperature at 50 p.s.i. for 3 hours.

Workup

  1. customhydrogenated at room temperature

Sources & evidence

ORD record
ord-d9182cbe95374082b02e1cfd578ba641
Source dataset
uspto-grants-2001_05
Patent number
US06235742B1

Reaction notes

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