Hydrochloric Acid → HCID 135815256, compound

HRID 1977635Notes

Reaction equation

HRID 1977635 reaction equation
[CH3:1][N:2]1[C:10]2[C:9](=[O:11])[NH:8][C:7]([CH2:12][C:13]3[CH:18]=[CH:17][C:16]([S:19](Cl)(=[O:21])=[O:20])=[CH:15][CH:14]=3)=[N:6][C:5]=2[C:4]([CH2:23][CH2:24][CH3:25])=[N:3]1.Cl.[OH-:27].[Na+]>>[CH3:1][N:2]1[C:10]2[C:9](=[O:11])[NH:8][C:7]([CH2:12][C:13]3[CH:18]=[CH:17][C:16]([S:19]([OH:27])(=[O:21])=[O:20])=[CH:15][CH:14]=3)=[N:6][C:5]=2[C:4]([CH2:23][CH2:24][CH3:25])=[N:3]1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 135815255HCID 135815255, compound

Product 1

HCID 135815256HCID 135815256, compound

Procedure

A solution of 4-[(1-methyl-7-oxo-3-propyl-6,7-dihydro-1H-pyrazolo[4,3-d]pyrimidin-5-yl)methyl]-1-benzenesulfonyl chloride (250 mg, 0.00065 mol) in 1N aqueous sodium hydroxide solution (3 ml) was stirred at room temperature for 2 hours. The reaction was acidified to pH1 with 2N aqueous hydrochloric acid and the resulting crystals filtered, washed with water, and dried by air suction, to yield the title compound (178 mg), m.p.>350° C.

Workup

  1. filtrationthe resulting crystals filtered
  2. washwashed with water
  3. customdried by air suction

Sources & evidence

ORD record
ord-66ed03f4a1f54d80b9e1012884e703da
Source dataset
uspto-grants-2001_05
Patent number
US06235742B1

Reaction notes

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