Ammonia → HCID 136052911, compound

HRID 1977636Notes

Reaction equation

HRID 1977636 reaction equation
[OH:1][CH2:2][C@H:3]([NH:8][S:9]([C:12]1[CH:17]=[CH:16][C:15]([CH2:18][C:19]2[NH:20][C:21](=[O:32])[C:22]3[N:27]([CH3:28])[N:26]=[C:25]([CH2:29][CH2:30][CH3:31])[C:23]=3[N:24]=2)=[CH:14][CH:13]=1)(=[O:11])=[O:10])[C:4]([O:6]C)=O.[NH3:33]>>[OH:1][CH2:2][C@H:3]([NH:8][S:9]([C:12]1[CH:13]=[CH:14][C:15]([CH2:18][C:19]2[NH:20][C:21](=[O:32])[C:22]3[N:27]([CH3:28])[N:26]=[C:25]([CH2:29][CH2:30][CH3:31])[C:23]=3[N:24]=2)=[CH:16][CH:17]=1)(=[O:10])=[O:11])[C:4]([NH2:33])=[O:6]

Participants

3

Reactant 2

HCID 222AmmoniaHCID 136052909HCID 136052909, compound

Product 1

HCID 136052911HCID 136052911, compound

Procedure

Methyl (2S)-3-hydroxy-2-({4-[(1-methyl-7-oxo-3-propyl-6,7-dihydro-1H-pyrazolo[4,3-d]pyrimidin-5-yl)methyl]phenyl}sulfonamido)propanoate (280 mg, 0.0006 mol) was dissolved in 0.880 aqueous ammonia solution (10 ml), and stirred at room temperature for 60 hours. The reaction mixture was then concentrated under reduced pressure, suspended in water (10 ml), then re-concentrated under reduced pressure. Crystallisation from ethanol gave the title compound (192 mg), m.p.226-229° C.

Workup

  1. concentrationThe reaction mixture was then concentrated under reduced pressure
  2. concentrationre-concentrated under reduced pressure
  3. customCrystallisation from ethanol

Sources & evidence

ORD record
ord-0a1da76dbdc146168b6fc676f69682b1
Source dataset
uspto-grants-2001_05
Patent number
US06235742B1

Reaction notes

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