Ammonia → HCID 136052911, compound

Participants

Reaction Steps

Methyl (2S)-3-hydroxy-2-({4-[(1-methyl-7-oxo-3-propyl-6,7-dihydro-1H-pyrazolo[4,3-d]pyrimidin-5-yl)methyl]phenyl}sulfonamido)propanoate (280 mg, 0.0006 mol) was dissolved in 0.880 aqueous ammonia solution (10 ml), and stirred at room temperature for 60 hours. The reaction mixture was then concentrated under reduced pressure, suspended in water (10 ml), then re-concentrated under reduced pressure. Crystallisation from ethanol gave the title compound (192 mg), m.p.226-229° C.

Provenance & Evidence