Acetic Acid → HCID 135815270, compound

HRID 1977640Notes

Reaction equation

HRID 1977640 reaction equation
Cl[CH:2]([C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1)[C:3](Cl)=O.[NH2:12][C:13]1[C:14]([CH2:22][CH2:23][CH3:24])=[N:15][N:16]([CH3:21])[C:17]=1[C:18]([NH2:20])=[O:19].[C:25]([OH:28])(=[O:27])[CH3:26]>>[C:25]([O:28][CH:2]([C:3]1[NH:20][C:18](=[O:19])[C:17]2[N:16]([CH3:21])[N:15]=[C:14]([CH2:22][CH2:23][CH3:24])[C:13]=2[N:12]=1)[C:6]1[CH:7]=[CH:8][CH:9]=[CH:10][CH:11]=1)(=[O:27])[CH3:26]

Participants

4

Reactant 3

HCID 176Acetic AcidHCID 102902Chloro(phenyl)acetyl chlorideHCID 33380444-Amino-1-methyl-3-propyl-1H-pyrazole-5-carboxamide

Product 1

HCID 135815270HCID 135815270, compound

Procedure

2-chloro-2-phenylacetyl chloride (3.47 ml, 0.022 mol) was added dropwise to a solution of 4-amino-3-propyl-1-methyl-5-pyrazolecarboxamide (4 g, 0.022 mol) in acetic acid (30 ml) and the reaction stirred at reflux under a nitrogen atmosphere for 20 hours.

Workup

  1. temperatureat reflux under a nitrogen atmosphere for 20 hours

Sources & evidence

ORD record
ord-8966729b39cd4cf981735bdddac69518
Source dataset
uspto-grants-2001_05
Patent number
US06235742B1

Reaction notes

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