2-Fluoroaniline → HCID 13588483, compound

HRID 1977646Notes

Reaction equation

HRID 1977646 reaction equation
C(O[C:4]([C:6]1[NH:10][CH:9]=[N:8][C:7]=1[CH3:11])=[O:5])C.C(=O)([O-])[O-].[K+].[K+].[F:18][C:19]1[CH:25]=[CH:24][CH:23]=[CH:22][C:20]=1[NH2:21]>>[F:18][C:19]1[CH:25]=[CH:24][CH:23]=[CH:22][C:20]=1[NH:21][C:4]([C:6]1[N:10]=[CH:9][NH:8][C:7]=1[CH3:11])=[O:5]

Participants

4

Reactant 3

HCID 95842-FluoroanilineHCID 11430Potassium CarbonateHCID 178470400HCID 178470400, compound

Product 1

HCID 13588483HCID 13588483, compound

Procedure

To ethyl-4-methyl-5-imidazolecarboxylate (5 g, 32.4 mmol) was added 20 mL of 2-fluoroaniline and potassium carbonate (8.9 g, 64.8 mmol). The reaction mixture was heated to reflux for 18 h then cooled to room temperature and concentrated in vacuo. Water and hexane were added and the precipitate filtered to give the crude product.

Workup

  1. temperatureThe reaction mixture was heated
  2. temperatureto reflux for 18 h
  3. concentrationconcentrated in vacuo
  4. additionWater and hexane were added
  5. filtrationthe precipitate filtered

Sources & evidence

ORD record
ord-4df7cdd8d1bf410486a4c8ede1513b61
Source dataset
uspto-grants-2001_05
Patent number
US06235740B1

Reaction notes

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