Acetanilide → HCID 21993592, compound

HRID 1977657Notes

Reaction equation

HRID 1977657 reaction equation
[C:1]([NH:4][C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1)(=[O:3])[CH3:2].Br[C:12]1[CH:13]=[N:14][CH:15]=[N:16][CH:17]=1>>[N:14]1[CH:13]=[C:12]([N:4]([C:1](=[O:3])[CH3:2])[C:5]2[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=2)[CH:17]=[N:16][CH:15]=1

Participants

3

Reactant 2

HCID 904AcetanilideHCID 783445-Bromopyrimidine

Product 1

HCID 21993592HCID 21993592, compoundYield 61%

Procedure

Using acetanilide (8.25 g) and 5-bromopyrimidine, a reaction was made in the same manner as in 1) of Production Example 2. The subsequent purification by silica gel column chromatography (developing solvent, ethyl acetate:hexane=1:1 to 3:1) produced N-(5-pyrimidinyl)acetanilide (7.98 g; yield, 61%) as a pale yellow oil.

Workup

  1. customThe subsequent purification by silica gel column chromatography (developing solvent, ethyl acetate:hexane=1:1 to 3:1)

Sources & evidence

ORD record
ord-c4e64b616c644b0b812c1b4944b91f5d
Source dataset
uspto-grants-2001_05
Patent number
US06235730B1

Reaction notes

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