2-Bromopyridine → HCID 21993584, compound

HRID 1977664Notes

Reaction equation

[Cl:1][CH2:2][C:3]([NH:5][C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1)=[O:4].Br[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][N:14]=1>>[Cl:1][CH2:2][C:3]([N:5]([C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][N:14]=1)[C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1)=[O:4]

Participants

Reactant 2

HCID 79732-Bromopyridine

HCID 11485Chloroacetanilide

Product 1

HCID 21993584HCID 21993584, compoundYield 93%

Procedure

Using 2-chloro-acetanilide (5.1 g) and 2-bromopyridine (9.5 g), a reaction was made in the same manner as in 1) of Production Example 14. The subsequent purification by silica gel column chromatography (developing solvent, ethyl acetate:hexane=1:2 to 1:1) produced 2-chloro-N-(2-pyridyl)acetanilide (6.9 g, crude product) as a red oil.

Workup

customThe subsequent purification by silica gel column chromatography (developing solvent, ethyl acetate:hexane=1:2 to 1:1)

Sources & evidence

ORD record: ord-3c34f9e939124f8ea63030450466c1d6
Source dataset: uspto-grants-2001_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06235730B1

Reaction notes

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