Hydrazine hydrate (1:1) → HCID 11230848, compound

HRID 1977675Notes

Reaction equation

HRID 1977675 reaction equation
[CH3:1][C:2]1[CH:18]=[C:17]([CH3:19])[CH:16]=[C:15]([CH3:20])[C:3]=1[C:4]([C:6]1[CH:14]=[CH:13][CH:12]=[CH:11][C:7]=1[C:8](O)=[O:9])=O.O.[NH2:22][NH2:23]>CCO>[CH3:1][C:2]1[CH:18]=[C:17]([CH3:19])[CH:16]=[C:15]([CH3:20])[C:3]=1[C:4]1[C:6]2[C:7](=[CH:11][CH:12]=[CH:13][CH:14]=2)[C:8](=[O:9])[NH:23][N:22]=1

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 348957MLS003373803

Product 1

HCID 11230848HCID 11230848, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A mixture of 2-(2,4,6-trimethylbenzoyl-benzoic acid (5.0 g, 18.7 mmol) and hydrazine hydrate (2 mL) in 15 mL of EtOH was stirred at reflux for 8 hours. The solvent was then removed from the mixture. The residue was heated to melt for about 10 minutes and then solidified by cooling. The resulting yellow solids were triturated with ether and filtered. The solid was washed with 1 N NaOH and water, and dried to give 1.8 g of titled compound as yellow solids, m.p. 259-62° C.

Workup

  1. temperatureat reflux for 8 hours
  2. customThe solvent was then removed from the mixture
  3. temperatureThe residue was heated
  4. temperatureby cooling
  5. customThe resulting yellow solids were triturated with ether
  6. filtrationfiltered
  7. washThe solid was washed with 1 N NaOH and water
  8. customdried

Sources & evidence

ORD record
ord-7d5e15331b1f444489b005130ca44a89
Source dataset
uspto-grants-2001_05
Patent number
US06235752B1

Reaction notes

Loading…