Hydrazine hydrate (1:1) → HCID 21995356, compound

HRID 1977677Notes

Reaction equation

HRID 1977677 reaction equation
C1(=O)[N:5]([CH2:6][CH2:7][CH2:8][O:9][C:10]2[CH:15]=[CH:14][C:13]([C:16]3[CH:21]=[CH:20][N:19]=[C:18]([NH:22][C:23]4[CH:28]=[C:27]([O:29][CH3:30])[C:26]([O:31][CH3:32])=[C:25]([O:33][CH3:34])[CH:24]=4)[N:17]=3)=[CH:12][CH:11]=2)C(=O)C2=CC=CC=C12.O.NN>>[NH2:5][CH2:6][CH2:7][CH2:8][O:9][C:10]1[CH:15]=[CH:14][C:13]([C:16]2[CH:21]=[CH:20][N:19]=[C:18]([NH:22][C:23]3[CH:28]=[C:27]([O:29][CH3:30])[C:26]([O:31][CH3:32])=[C:25]([O:33][CH3:34])[CH:24]=3)[N:17]=2)=[CH:12][CH:11]=1

Participants

3

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 21995252HCID 21995252, compound

Product 1

HCID 21995356HCID 21995356, compoundYield 10%

Procedure

The compound was prepared in a manner analogous to the preparation of the compound of Example 48 from the compound of Example 50 (830 mg, 1.54 mmol) and hydrazine monohydrate (0.23 ml, 4.62 mmol) to give the title compound (63 mg) as a white solid m.p. 161-162°. MS m/z 411(M+H)+.

Sources & evidence

ORD record
ord-9d3a7753dace4894afc33a0ae60c95d8
Source dataset
uspto-grants-2001_05
Patent number
US06235746B1

Reaction notes

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