反应详情

A solution of 4-fluoro-3-phenoxybenzyl bromide (42.17 g, 0.150 mol) in toluene is added to a solution of triphenyl phosphine (41.31 g, 0.158 mol) in toluene. The resultant reaction mixture is refluxed for one hour, cooled to room temperature, and filtered to obtain a solid. The solid is washed sequentially with toluene and hexanes, and dried in a dessicator at 60° C. to give the title product (73.7 g, 90.4%) which is identified by NMR spectral analyses.

1. customThe resultant reaction mixture
2. temperatureis refluxed for one hour
3. filtrationfiltered
4. customto obtain a solid
5. washThe solid is washed sequentially with toluene and hexanes
6. customdried in a dessicator at 60° C.