5-Methoxy-6-(trifluoromethyl)indoline → HCID 10670813, compound

HRID 1977772Notes

Reaction equation

HRID 1977772 reaction equation
[CH2:1]([C:3]1[CH:4]=[C:5]([NH:15][C:16](=[O:24])OC2C=CC=CC=2)[CH:6]=[C:7]([C:9]2[CH:10]=[N:11][CH:12]=[CH:13][CH:14]=2)[CH:8]=1)[CH3:2].[CH3:25][O:26][C:27]1[CH:28]=[C:29]2[C:33](=[CH:34][C:35]=1[C:36]([F:39])([F:38])[F:37])[NH:32][CH2:31][CH2:30]2>CN(C=O)C>[CH2:1]([C:3]1[CH:8]=[C:7]([C:9]2[CH:10]=[N:11][CH:12]=[CH:13][CH:14]=2)[CH:6]=[C:5]([NH:15][C:16]([N:32]2[C:33]3[C:29](=[CH:28][C:27]([O:26][CH3:25])=[C:35]([C:36]([F:38])([F:39])[F:37])[CH:34]=3)[CH2:30][CH2:31]2)=[O:24])[CH:4]=1)[CH3:2]

Participants

4

Reactant 2

HCID 112067135-Methoxy-6-(trifluoromethyl)indolineHCID 18005169HCID 18005169, compound

Product 1

HCID 10670813HCID 10670813, compoundYield 41.9%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

The title compound (0.15 g, 40%) was prepared as a tan powder using the methodology of Example 28 from phenyl N-(3-ethyl-5-(pyrid-3-yl)phenyl carbamate (D30) (0.26 g, 0.81 mmol) and 5-methoxy-6-trifluoromethylindoline (D11) (0.177 g, 0.81 mmol) in DMF (10 ml). Melting point: 204° C.-207° C.

Sources & evidence

ORD record
ord-c4fef47ed5d7462f9ce30555c0621dfd
Source dataset
uspto-grants-2001_05
Patent number
US06235758B1

Reaction notes

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