Phenoxycarbonyl isothiocyanate → HCID 178491731, compound

HRID 1977836Notes

Reaction equation

HRID 1977836 reaction equation
[CH3:1][O:2][C:3]1[CH:15]=[CH:14][C:6]([CH2:7][S:8][C:9](=[NH:13])[CH2:10][C:11]#[N:12])=[CH:5][CH:4]=1.[O:16]([C:23]([N:25]=[C:26]=[S:27])=[O:24])[C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1>C(OCC)(=O)C.CCOCC>[CH3:1][O:2][C:3]1[CH:15]=[CH:14][C:6]([CH2:7][S:8][C:9](=[NH:13])[C:10]([C:11]#[N:12])=[C:26]([SH:27])[NH:25][C:23]([O:16][C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)=[O:24])=[CH:5][CH:4]=1

Participants

5

Reactant 2

HCID 12212046Phenoxycarbonyl isothiocyanateHCID 205771932-Cyano-thioacetimidic acid 4-methoxy-benzyl ester

Product 1

HCID 178491731HCID 178491731, compoundYield 73.8%

Reagents, catalysts & solvents 2

HCID 3283Diethyl EtherSolventHCID 8857Ethyl AcetateSolvent

Conditions

Temperature
0 °C

Procedure

To a solution of of 2-cyano-thioacetimidic acid 4-methoxy-benzyl ester (42 g, 0.19 mol) in 191 mL of ethyl acetate at 0° C. was added phenoxycarbonylisothiocyanate (34 g, 0.19 mol), and the mixture was stirred at 0° C. for 24 hours. The mixture was diluted with ether and filtered. The solids were washed with ether, collected and dried in vacuo, affording 56 g (73%) of 2-cyano-3-mercapto-3-phenoxycarbonylamino-thioacrylimidic acid 4-methoxy-benzyl ester as a yellow solid. 1H NMR (400 MHz, CDCl3) δ12.81(s, 1H), 9.01 (s, 1H), 8.68 (s, 1H) 7.28-6.99 (m, 7H), 6.69 (d, 2H, J=8.8 Hz), 4.17 (s, 2H), 3.64 (s, 3H) ppm; MS (APCI, m/z): 400 [M+H]+.

Workup

  1. filtrationfiltered
  2. washThe solids were washed with ether
  3. customcollected
  4. customdried in vacuo

Sources & evidence

ORD record
ord-e83e03879953476f8a679c6e28cf23b5
Source dataset
uspto-grants-2001_05
Patent number
US06235764B1

Reaction notes

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