Iodoacetamide → HCID 54268875, compound

HRID 1977912Notes

Reaction equation

HRID 1977912 reaction equation
I[CH2:2][C:3]([NH2:5])=[O:4].[NH:6]1[CH2:11][CH2:10][CH:9]([C:12]2[CH:17]=[CH:16][C:15]([C:18]3[N:23]=[C:22]([NH2:24])[CH:21]=[CH:20][CH:19]=3)=[CH:14][CH:13]=2)[CH2:8][CH2:7]1>>[C:3]([NH:5][N:6]1[CH2:11][CH2:10][CH:9]([C:12]2[CH:13]=[CH:14][C:15]([C:18]3[N:23]=[C:22]([NH2:24])[CH:21]=[CH:20][CH:19]=3)=[CH:16][CH:17]=2)[CH2:8][CH2:7]1)(=[O:4])[CH3:2]

Participants

3

Reactant 2

HCID 3727IodoacetamideHCID 21995458HCID 21995458, compound

Product 1

HCID 54268875HCID 54268875, compound

Procedure

Prepared from Example 13, using iodoacetamide to alkylate 6-[4-(piperidin-4-yl)-phenyl]-pyridin-2-ylamine, in 55%, mp 224-227° C.

Workup

  1. customPrepared from Example 13

Sources & evidence

ORD record
ord-e42795b3eab344f4bf1ccc07b1ee67bc
Source dataset
uspto-grants-2001_05
Patent number
US06235750B1

Reaction notes

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