反应详情

温度

100 °C

A mixture of 4-(3-bromopropyl)-6-methoxy-1,2-dihydronaphthalene (10 g, 35.6 mmol), potassium phthalimide (7.9 g, 42.7 mmol) and DMF (50 ml ) was heated at 100° C. for 1 hour and then cooled. The mixture was diluted with water and the product was extracted with ethyl acetate. The extract was washed with brine and water, dried over anhydrous magnesium sulfate, and the solvent was removed in vacuo. The residue was purified by a silica gel column chromatography (ethyl acetate:hexane=2:8) to afford the titled compound (11.8 g, yield 95%, oil).

1. temperaturecooled
2. extractionthe product was extracted with ethyl acetate
3. washThe extract was washed with brine and water
4. dry with materialdried over anhydrous magnesium sulfate
5. customthe solvent was removed in vacuo
6. customThe residue was purified by a silica gel column chromatography (ethyl acetate:hexane=2:8)