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Hydrazine hydrate (1:1) → 3-(7-Methoxy-3,4-dihydronaphthalen-1-yl)propylamine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrazine hydrate (1:1) | HCID 24654 | — |
| 反応物 | 2-[3-(7-Methoxy-3,4-dihydronaphthalen-1-yl)propyl]isoindole-1,3-dione | HCID 21996455 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | 3-(7-Methoxy-3,4-dihydronaphthalen-1-yl)propylamine | HCID 21996439 | 77.1% |
反応手順
A solution of 2-[3-(7-methoxy-3,4-dihydronaphthalen-1-yl)propyl]isoindole-1,3-dione (11.8 g, 34.0 mmol) and hydrazine monohydrate (5.1 g, 0.1 mol) in ethanol (150 ml) was refluxed for 1 hour and then cooled in an ice bath. The resulting insoluble material was removed by filtration and the solvent was removed in vacuo to afford the titled compound (5.7 g, yield 77%, oil). This compound was provided for the next reaction without further purification.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06235789B1 |
| 出典データセット | uspto-grants-2001_05 |
| ORD ID | ord-af56849791bb4deca5d61a272d0fdf17 |
| 出典メモ | uspto-grants-2001_05 |