反应详情

To a solution of 1-(2-aminoethyl)-6-methoxyindan (0.80 g, 4.18 mmol) and triethylamine (0.44 g, 4.39 mmol) in dichloromethane (15 ml) was gradually added dropwise, under ice cooling, acetyl chloride (0.33 g, 4.18 mmol). The mixture was stirred for 10 minutes at room temperature. The reaction mixture was poured into water. The organic layer was subjected to extraction with chloroform. The extract solution was washed with 1N hydrochloric acid, a saturated aqueous solution of sodium hydrogencarbonate and brine, which was dried over anhydrous magnesium sulfate, followed by distilling off the solvent under reduced pressure. The residue was recrystallized from ethyl acetate/isopropyl ether to give the above-titled compound (yield 0.68 g, 70%).

1. extractionThe organic layer was subjected to extraction with chloroform
2. washThe extract solution was washed with 1N hydrochloric acid
3. dry with materiala saturated aqueous solution of sodium hydrogencarbonate and brine, which was dried over anhydrous magnesium sulfate
4. distillationby distilling off the solvent under reduced pressure
5. customThe residue was recrystallized from ethyl acetate/isopropyl ether