1-[2-(Acetylamino)ethyl]-6-methoxyindan → (s)-1-[2-(Acetylamino)ethyl]-6-methoxyindan

HRID 1978019Notes

Reaction equation

HRID 1978019 reaction equation
[C:1]([NH:4][CH2:5][CH2:6][CH:7]1[C:15]2[C:10](=[CH:11][CH:12]=[C:13]([O:16][CH3:17])[CH:14]=2)[CH2:9][CH2:8]1)(=[O:3])[CH3:2]>C(Cl)(Cl)Cl>[C:1]([NH:4][CH2:5][CH2:6][C@H:7]1[C:15]2[C:10](=[CH:11][CH:12]=[C:13]([O:16][CH3:17])[CH:14]=2)[CH2:9][CH2:8]1)(=[O:3])[CH3:2]

Participants

3

Reactant 1

HCID 155239391-[2-(Acetylamino)ethyl]-6-methoxyindan

Product 1

HCID 10988162(s)-1-[2-(Acetylamino)ethyl]-6-methoxyindan

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

By substantially the same procedure as in Working Example 65, 1-[2-(acetylamino)ethyl]-6-methoxyindan was subjected to optical resolution by means of a high performance liquid chromatography to give the above-titled compound (119 mg), m.p.93-94° C. [α]Hg365 +80.7° (c 0.3, CHCl3).

Sources & evidence

ORD record
ord-41d58bf37abb4a7bb7738de8cea8386d
Source dataset
uspto-grants-2001_05
Patent number
US06235789B1

Reaction notes

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