Trifluoroacetic anhydride → HCID 22880382, compound

HRID 1978087Notes

Reaction equation

HRID 1978087 reaction equation
[C:1]([C@H:4]([CH2:10][CH:11]([CH3:13])[CH3:12])[C@H:5]([OH:9])[C:6]([OH:8])=[O:7])([OH:3])=[O:2].F[C:15](F)(F)C(OC(=O)C(F)(F)F)=O>>[C:1]([C@H:4]([CH2:10][CH:11]([CH3:13])[CH3:12])[C@H:5]([OH:9])[C:6]([O:8][CH3:15])=[O:7])([OH:3])=[O:2]

Participants

3

Reactant 2

HCID 9845Trifluoroacetic anhydrideHCID 10845347157604-22-3

Product 1

HCID 22880382HCID 22880382, compound

Procedure

4.48 g of 3(R)-carboxy-2(S)-hydroxy-5-methylhexanoic acid were stirred under nitrogen in 10 ml of trifluoroacetic anhydride for 1.5 hours. The solvent was evaporated and the residue was dissolved in 20 ml of dry methanol and stirred overnight at room temperature. The solvent was evaporated to give 5.3 g of methyl 3(R)-carboxy-2(S)-hydroxy-5-methylhexanoate in the form of an orange oil.

Workup

  1. customThe solvent was evaporated
  2. dissolutionthe residue was dissolved in 20 ml of dry methanol
  3. customThe solvent was evaporated

Sources & evidence

ORD record
ord-6efa1773777f44bab4707db4573dc354
Source dataset
uspto-grants-2001_05
Patent number
US06235787B1

Reaction notes

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