Methanesulfonic Acid → HCID 86756762, compound

Participants

Reaction Steps

In a manner to that described in the first paragraph of Example 2, but using methanesulphonic acid in place of p-toluenesulphonic acid, starting from 0.049 g of (E)-2(R)-[1(S)-[(tetrahydro-2-(RS)pyranyloxy)carbamoyl]-4-phenyl-3-butenyl]-2′-(methanesulphonyl)-4-methyl-2′-(2,6-dimethyl-4-pyrimidinyl)valerohydrazide there was obtained 0.039 g of (E)-2(R)-[1(S)-(hydroxycarbamoyl)-4-phenyl-3-butenyl]-2′-(methanesulphonyl)-4-methyl-2′-(2,6-dimethyl-4-pyrimidinyl)valerohydrazide methanesulphonate in the form of an off-white solid.

Provenance & Evidence