Methanesulfonic Acid → HCID 86756762, compound

HRID 1978096Notes

Reaction equation

[CH3:1][S:2]([OH:5])(=[O:4])=[O:3].O1CCCCC1[O:12][NH:13][C:14]([C@H:16]([C@@H:26]([CH2:43][CH:44]([CH3:46])[CH3:45])[C:27]([NH:29][N:30]([S:39]([CH3:42])(=[O:41])=[O:40])[C:31]1[CH:36]=[C:35]([CH3:37])[N:34]=[C:33]([CH3:38])[N:32]=1)=[O:28])[CH2:17]/[CH:18]=[CH:19]/[C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1)=[O:15]>>[CH3:1][S:2]([OH:5])(=[O:4])=[O:3].[OH:12][NH:13][C:14]([C@H:16]([C@@H:26]([CH2:43][CH:44]([CH3:46])[CH3:45])[C:27]([NH:29][N:30]([S:39]([CH3:42])(=[O:41])=[O:40])[C:31]1[CH:36]=[C:35]([CH3:37])[N:34]=[C:33]([CH3:38])[N:32]=1)=[O:28])[CH2:17]/[CH:18]=[CH:19]/[C:20]1[CH:21]=[CH:22][CH:23]=[CH:24][CH:25]=1)=[O:15]

Participants

Reactant 2

HCID 6395Methanesulfonic Acid

HCID 86756764HCID 86756764, compound

Product 1

HCID 86756762HCID 86756762, compound

Procedure

In a manner to that described in the first paragraph of Example 2, but using methanesulphonic acid in place of p-toluenesulphonic acid, starting from 0.049 g of (E)-2(R)-[1(S)-[(tetrahydro-2-(RS)pyranyloxy)carbamoyl]-4-phenyl-3-butenyl]-2′-(methanesulphonyl)-4-methyl-2′-(2,6-dimethyl-4-pyrimidinyl)valerohydrazide there was obtained 0.039 g of (E)-2(R)-[1(S)-(hydroxycarbamoyl)-4-phenyl-3-butenyl]-2′-(methanesulphonyl)-4-methyl-2′-(2,6-dimethyl-4-pyrimidinyl)valerohydrazide methanesulphonate in the form of an off-white solid.

Sources & evidence

ORD record: ord-94e8c25ba1be45c99a5be7d23f3d1381
Source dataset: uspto-grants-2001_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06235787B1

Reaction notes

Loading…