Oxygen → Methyl 3-hydroxyadamantane-1-carboxylate
Reaction equation
[O:1]=O.[CH3:3][O:4][C:5]([C:7]12[CH2:16][CH:11]3[CH2:12][CH:13]([CH2:15][CH:9]([CH2:10]3)[CH2:8]1)[CH2:14]2)=[O:6]>>[CH3:3][O:4][C:5]([C:7]12[CH2:16][CH:11]3[CH2:12][CH:13]([CH2:15][C:9]([OH:1])([CH2:10]3)[CH2:8]1)[CH2:14]2)=[O:6]Participants
3
Procedure
The oxidization in an oxygen atmosphere was conducted in the same manner as in Preparation Example 1 except that 1-methoxycarbonyladamantane was used instead of the adamantane, and, as a result, a 1-methoxycarbonyl-3-hydroxyadamantane (yield: 42%) and a 1-methoxycarbonyl-3,5-hydroxyadamantane (yield : 33%) were obtained with a conversion of 91%.
Sources & evidence
- ORD record
- ord-06c075dd70014f3daf776c4f4a9c7eff
- Source dataset
- uspto-grants-2001_05
- Patent number
- US06235851B1
Reaction notes
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