Sodium Methoxide → HCID 15022709, compound

HRID 1978146Notes

Reaction equation

HRID 1978146 reaction equation
[CH3:1][O-:2].[Na+].[Cl:4][C:5]1[N:10]=[C:9]([C:11]([Cl:14])([Cl:13])[Cl:12])[CH:8]=[C:7](Cl)[N:6]=1>ClCCCl>[Cl:4][C:5]1[N:6]=[C:7]([O:2][CH3:1])[CH:8]=[C:9]([C:11]([Cl:14])([Cl:13])[Cl:12])[N:10]=1

Participants

4

Reactant 2

HCID 10942334Sodium MethoxideHCID 12572978HCID 12572978, compound

Product 1

HCID 15022709HCID 15022709, compound

Reagents, catalysts & solvents 1

HCID 111,2-DichloroethaneSolvent

Conditions

Temperature
25 °C

Procedure

293.1 g (1.692 mol) of 30% strength sodium methylate solution were added over the course of 1½ hours to a stirred solution of 434 g (1.692 mol) of 2,6-dichloro-4-trichloromethylpyrimidine in 1 l of 1,2-dichloroethane at 0 to 5° C. The mixture was then stirred at 0 to 5° C. for 1 hour and at 25° C. for 12 hours and then extracted with water and with saturated brine. Drying over magnesium sulfate and concentration resulted in 423 g (95% of theory) of the title compound as an almost colorless oil.

Workup

  1. extractionextracted with water and with saturated brine
  2. dry with materialDrying over magnesium sulfate and concentration

Sources & evidence

ORD record
ord-ea3e6bbca873466aa8df65388a60abfa
Source dataset
uspto-grants-2001_05
Patent number
US06235904B1

Reaction notes

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