Sodium Methoxide → HCID 86747118, compound

HRID 1978155Notes

Reaction equation

HRID 1978155 reaction equation
[CH3:1][O-:2].[Na+].[Cl:4][C:5]1[C:10]([O:11][CH:12]([F:14])[F:13])=[C:9](F)[N:8]=[C:7]([NH:16][CH3:17])[N:6]=1>CO>[Cl:4][C:5]1[C:10]([O:11][CH:12]([F:14])[F:13])=[C:9]([O:2][CH3:1])[N:8]=[C:7]([NH:16][CH3:17])[N:6]=1

Participants

4

Reactant 2

HCID 10942334Sodium MethoxideHCID 21996923HCID 21996923, compound

Product 1

HCID 86747118HCID 86747118, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Conditions

Temperature
0 °C

Procedure

4.7 g (0.026 mol) of 30% strength sodium methylate were added over the course of 10 minutes to 6.0 g (0.0263 mol) of 4-chlorodifluoromethoxy-6-fluoro-2-methylaminopyrimidine in 100 ml of methanol while stirring at 0° C. The mixture was stirred at 0° C. and at 25° C. for 1 hour each and worked up as usual, resulting in 6.3 g (100% of theory) of the title compound of melting point 49-53° C.

Workup

  1. stirringThe mixture was stirred at 0° C. and at 25° C. for 1 hour each and

Sources & evidence

ORD record
ord-ed44251885af46e59028d44379fbfb4a
Source dataset
uspto-grants-2001_05
Patent number
US06235904B1

Reaction notes

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